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Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse
Marie N S Gendy1,2, Clement Zai3,4,5, Bernard Le Foll1,6,7,8,2,3,9
1Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, 33 Russell Street, Toronto, ON, Canada M5S 2S1.
Abstract:
Alcohol use disorder is a complex disorder that is influenced by genetic factors. The non-synonymous single-nucleotide polymorphism (SNP) rs1799971 in exon 1 in opioid receptor OPRM1 was extensively studied in patients with alcohol dependence with mixed findings. Moreover, studies showed that opioid receptor polymorphism might play a role in the pathophysiology of schizophrenia. Our results suggest that rs1799971 SNP is not significantly associated with alcohol dependence in our sample of Schizophrenia patients of European ancestry.
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