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Patients with diffuse idiopathic skeletal hyperostosis have an increased burden of thoracic aortic calcifications

Netanja I Harlianto1, Jan Westerink2, Marjolein E Hol1

  • 1Department of Radiology.

Rheumatology Advances in Practice
|August 22, 2022
PubMed

Insights

Diffuse idiopathic skeletal hyperostosis (DISH) is linked to more severe thoracic aortic calcification (TAC). This suggests DISH patients have a higher vascular calcification burden, increasing cardiovascular risk.

Area of Science:

  • Cardiovascular Medicine
  • Radiology
  • Rheumatology

Background:

  • Diffuse idiopathic skeletal hyperostosis (DISH) is associated with coronary artery calcification and ischemic stroke.
  • Bone formation in DISH may share pathophysiological pathways with aortic calcification.

Purpose of the Study:

  • To investigate the association between DISH and the presence and severity of thoracic aortic calcification (TAC).

Main Methods:

  • Cross-sectional study of 4703 patients from the Second Manifestation of ARTerial disease (ART) cohort.
  • DISH assessed using Resnick criteria on chest radiographs.
  • TAC severity graded from none to severe; logistic regression used for analysis.

Main Results:

  • 9.4% of patients had DISH; 38% had TAC.
  • DISH prevalence increased with TAC severity (6.6% to 17.1%).
  • DISH significantly associated with TAC (OR 1.46) and more strongly with moderate (OR 1.43) and severe TAC (OR 1.67).

Conclusions:

  • Patients with DISH exhibit significantly increased thoracic aortic calcification.
  • This finding supports the hypothesis that DISH is associated with a greater vascular calcification burden.
Abstract

Keywords:
atherosclerosisbone formationcalcificationdiffuse idiopathic skeletal hyperostosisthoracic aortic calcification

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