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Updated: Aug 31, 2025
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
Published on: May 25, 2017
A Golgi-targeted viscosity rotor for monitoring early alcohol-induced liver injury
Chuanhao Liu1,2, Lin Zhou2, Ying Zheng2
1Institute of Molecular Medicine & School of Biomedical Sciences, Huaqiao University, Quanzhou, 362021, China. xielijuan@hqu.edu.cn.
Abstract:
We proposed to monitor the early stage of alcohol-induced liver injury through quantitatively detecting Golgi viscosity. Therefore, the first Golgi-targeted fluorescent rotor (GA-Vis) was developed. With the aid of GA-Vis, the changes in Golgi viscosity during alcohol-induced liver injury were quantitatively evaluated by fluorescence lifetime imaging in live cells and zebrafish. GA-Vis was qualified as a practical tool for future diagnoses of alcohol-induced liver injury.
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