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Updated: Aug 31, 2025
Production of Nanofibrillar Patterned Collagen for Tissue Engineering
Published on: September 20, 2024
Collagen/physiologically clotted fibrin-based nanobioscaffold supported with silver nanoparticles: A novel approach
Rethinam Senthil1,2,3, Serdar Batıkan Kavukcu4, Thangavelu Lakshmi3
1Engineering Faculty, Leather Engineering Department, Ege University, Izmir, Turkey.
Purpose:
In this work, a blend of collagen, physiologically clotted fibrin (PCF), and silver nanoparticles (AgNPs) is used to develop a nanobioscaffold (NBS), for their possible application in wound dressing materials.
Methods:
The prepared NBS were evaluated using physicochemical, mechanical, and antibacterial properties. The NBS cell viability was demonstrated in a biocompatibility study using the human keratinocyte cell line (HaCaT).
Results:
The results demonstrated that the NBS had excellent tensile strength (22.15 ± 0.05 MPa), elongation at break (13.32 ± 0.09%), and water absorption (97.51 ± 0.08). The in-vitro study demonstrated its biocompatible nature. NBS exhibited significant antibacterial activity against the Gram-negative and Gram-positive bacteria.
Conclusion:
The NBS with required mechanical strength, antibacterial activity, and biocompatibility may be tested as a wound material in rats after getting the necessary approval.
