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Long noncoding RNA SNHG7-miRNA-mRNA axes crosstalk with oncogenic signaling pathways in human cancers

Faezeh Malakoti1, Forough Alemi1, Shirin Jafari Yeganeh2

  • 1Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Chemical Biology & Drug Design
|August 22, 2022
PubMed

Insights

Long non-coding RNAs (lncRNAs) like SNHG7 act as oncogenes by sponging microRNAs (miRNAs), influencing cancer development through lncRNA-miRNA-mRNA pathways and key signaling routes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are critical non-coding RNAs involved in cancer.
  • Dysregulated lncRNAs contribute to tumorigenesis and metastasis through various mechanisms.
  • lncRNAs can interact with miRNAs, affecting cellular processes, genomic stability, and cancer progression.

Purpose of the Study:

  • To provide an overview of the contribution of lncRNA SNHG7-miRNA-mRNA axes to cancer development.
  • To discuss the role of lncRNA SNHG7 in regulating gene expression and signaling pathways in cancer.
  • To explore lncRNA SNHG7's function as a competing endogenous RNA (ceRNA).

Main Methods:

  • Literature review and analysis of existing research on lncRNA SNHG7.
  • Examination of lncRNA-miRNA interactions and their downstream effects.
  • Investigation of signaling pathways modulated by lncRNA SNHG7, including Wnt/β-Catenin, PI3K/AKT/mTOR, SIRT1, and Snail-EMT.

Main Results:

  • LncRNA SNHG7 functions as an oncogene by sponging miRNAs.
  • SNHG7 participates in the formation of lncRNA-miRNA-mRNA axes.
  • These axes regulate critical cancer-related signaling pathways and gene expression.

Conclusions:

  • LncRNA SNHG7 plays a significant role in cancer development and progression.
  • Its mechanism involves acting as a ceRNA to modulate miRNA activity.
  • Understanding SNHG7-mediated pathways offers potential therapeutic targets for cancer treatment.
Keywords:
PI3K/AKT/mTORSIRT1SNHGsSnail-EMTWnt/β-cateninmalignancynon-coding RNAs

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