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Research Progress of Plant Active Ingredients in Pharmaceutical Cocrystal
Zimeng Wang1, Hongzhou Shang2, Linghuan Gao3
1College of Pharmacy, North China University of Science and Technology, Tangshan 063210, China.
Abstract:
The disadvantages of active ingredients extracted from medicinal plants due to poor solubility in the body and low bioavailability limit their clinical application. Pharmaceutical cocrystal as a new type of drug in solid form has attracted the attention of researchers. This article reviews the effects of cocrystal in various poorly soluble herbal active ingredients of medicinal plants on their physicochemical properties and biological properties and provides references for the application of pharmaceutical cocrystal in poorly soluble active compounds of medicinal plants.
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