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Microglia orchestrate neuroinflammation

Ricardo A Feldman1

  • 1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, United States.

Elife
|August 22, 2022
PubMed

Insights

Microglia, immune cells in the brain, are key players in the neurological damage seen in neuropathic Gaucher disease. These findings highlight microglia's role in disease progression.

Area of Science:

  • Neuroscience
  • Immunology
  • Genetics

Background:

  • Gaucher disease is a lysosomal storage disorder.
  • Neuropathic forms of Gaucher disease involve significant neurological complications.
  • The precise mechanisms driving neurological damage are not fully understood.
Keywords:
Gaucher diseaseGba1NK cellshumanlipidsmedicinemicrogliamouseneuroinflammation

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