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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Rheumatologic associations of microscopic colitis: A narrative review.

Christopher Le1, Noam Zeffren1, Neil Kramer2,3

  • 1Department of Medicine, Bayonne Medical Center, CarePoint Health, Bayonne, NJ, USA.

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|August 22, 2022
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Summary

Extraintestinal manifestations (EIMs) are common in microscopic colitis (MC). This review highlights rheumatologic conditions like rheumatoid arthritis and scleroderma as frequent comorbidities in MC patients, suggesting shared autoimmune links.

Keywords:
Autoantibodiescollagenous colitislymphocytic colitisrheumatoid arthritisspondyloarthropathy

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Area of Science:

  • Gastroenterology and Rheumatology
  • Autoimmune Diseases
  • Inflammatory Bowel Disease Spectrum

Background:

  • Extraintestinal manifestations (EIMs) are well-documented in Crohn's disease and ulcerative colitis.
  • EIMs in microscopic colitis (MC), including lymphocytic colitis and collagenous colitis, are less understood.
  • This review focuses on rheumatologic EIMs associated with MC.

Approach:

  • Comprehensive literature review of peer-reviewed journals and reports.
  • Searched PubMed Central and MEDLINE using keywords: 'microscopic colitis', 'lymphocytic colitis', 'collagenous colitis', 'inflammatory bowel disease', 'extraintestinal manifestations', and specific disease associations.
  • Analyzed reported rheumatologic manifestations and their association with MC.

Key Points:

  • A wide range of rheumatologic conditions present in MC patients.
  • Rheumatoid arthritis and limited scleroderma identified as notable comorbidities.
  • Inflammatory arthropathy frequently precedes or coincides with MC onset, with diverse presentations.
  • High incidence of autoantibodies suggests a potential autoimmune link.

Conclusions:

  • MC is associated with a broad spectrum of rheumatologic manifestations.
  • Further research, including a clinical registry, is needed to define EIM incidence and autoimmune rheumatic disease associations in MC.
  • Understanding shared predispositions and pathogenic mechanisms may reveal therapeutic opportunities.