Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating Chronic Sex-Specific Changes in Glutamatergic Signaling Markers Following Traumatic Brain Injury.

International journal of molecular sciences·2026
Same author

Mechanistic modeling of amyloid dynamics relating to Alzheimer's disease progression.

Frontiers in aging neuroscience·2026
Same author

Chronic dynamic behavioral changes and upregulation of glutamatergic signaling proteins following traumatic brain injury in females.

Brain research·2025
Same author

Repetitive Blast Exposure Drives Chronic Pain in Female Rats.

Journal of neuroscience research·2025
Same author

Quasi-3D Mechanistic Model for Predicting Eye Drop Distribution in the Human Tear Film.

Bioengineering (Basel, Switzerland)·2025
Same author

Integrative Constraint-Based Modeling and Proteomics Uncover Astrocytic Metabolic Adaptations to the Post-TBI Microenvironment.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Aug 31, 2025

Author Spotlight: Advancing Traumatic Brain Injury Research - A Closed-Head Model for Accurate Replication and Rapid Assessment
08:07

Author Spotlight: Advancing Traumatic Brain Injury Research - A Closed-Head Model for Accurate Replication and Rapid Assessment

Published on: September 22, 2023

1.5K

Defining Experimental Variability in Actuator-Driven Closed Head Impact in Rats.

Caiti-Erin Talty1, Carly Norris2, Pamela VandeVord3,4

  • 1Graduate Program in Translational Biology, Medicine and Health, Virginia Tech, Blacksburg, VA, USA.

Annals of Biomedical Engineering
|August 22, 2022
PubMed
Summary

Actuator-driven closed head impact (AD-CHI) models offer versatile preclinical tools for studying traumatic brain injury (TBI). Standardizing methods in AD-CHI rat models is crucial for improving the translational value of TBI research.

Keywords:
ConcussionMethodsPreclinicalTraumatic brain injuryValidation

More Related Videos

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

3.3K
Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration
06:14

Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration

Published on: May 9, 2020

8.5K

Related Experiment Videos

Last Updated: Aug 31, 2025

Author Spotlight: Advancing Traumatic Brain Injury Research - A Closed-Head Model for Accurate Replication and Rapid Assessment
08:07

Author Spotlight: Advancing Traumatic Brain Injury Research - A Closed-Head Model for Accurate Replication and Rapid Assessment

Published on: September 22, 2023

1.5K
Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury
09:49

Assessing Changes in Synaptic Plasticity Using an Awake Closed-Head Injury Model of Mild Traumatic Brain Injury

Published on: January 20, 2023

3.3K
Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration
06:14

Induction of Diffuse Axonal Brain Injury in Rats Based on Rotational Acceleration

Published on: May 9, 2020

8.5K

Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Translational Research

Background:

  • Traumatic brain injury (TBI) presents a global health challenge with limited diagnostic and therapeutic tools.
  • Developing reproducible preclinical models is essential for advancing TBI clinical tools.
  • Existing TBI models often lack the necessary translational value due to study diversity.

Purpose of the Study:

  • To review and identify sources of experimental variability in actuator-driven closed head impact (AD-CHI) rat models.
  • To enhance the translational value of AD-CHI models for TBI research.
  • To support the standardization of AD-CHI protocols for improved reproducibility.

Main Methods:

  • Review of existing literature on actuator-driven closed head impact (AD-CHI) models in rats.
  • Identification of key parameters and potential sources of variability in AD-CHI protocols.
  • Analysis of AD-CHI model application in pediatric and repeated TBI paradigms.

Main Results:

  • AD-CHI models offer translational advantages for TBI by replicating pathophysiological and behavioral outcomes.
  • Key advantages include versatile impact parameters (angle, velocity, depth, dwell time) and interchangeable tip types, avoiding craniectomy.
  • Primary sources of variability identified include head stabilization, tip property reporting, and acute neurological assessments.

Conclusions:

  • Standardizing head stabilization, tip properties, and neurological assessments in AD-CHI models is critical.
  • Further characterization of AD-CHI models will improve their translational value in TBI research.
  • Establishing relationships between impact parameters and injury outcomes will reduce variability and foster common data elements in the TBI research community.