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Lead exposure and antisocial behavior: A systematic review protocol
Rachel M Shaffer1, Jenna E Forsyth2, Greg Ferraro3
1US Environmental Protection Agency, Center for Public Health and Environmental Assessment, Washington, DC, and Research Triangle Park, NC, United States.
Environment International
|August 22, 2022
Summary
This systematic review examines the link between lead exposure and antisocial behavior. Findings will inform global efforts to reduce lead exposure and its associated health risks.
Area of Science:
- Environmental Health
- Toxicology
- Developmental Psychology
Background:
- Lead exposure is a global public health issue with known adverse health effects.
- Emerging evidence links lead exposure to antisocial behaviors like aggression and crime.
- A comprehensive review is needed to advance scientific understanding and policy.
Purpose of the Study:
- To systematically review the association between lead exposure and antisocial behavior.
- To evaluate human epidemiological and nonhuman mammalian experimental studies.
Main Methods:
- Systematic review protocol following COSTER and U.S. EPA IRIS guidelines.
- Searched PubMed, BIOSIS, Web of Science; results stored in HERO database.
- Included human studies on various antisocial outcomes and animal studies on aggression and fear/anxiety responses.
Main Results:
- Data extraction and screening aided by AI.
- Two independent reviewers assessed study relevance and eligibility.
- Narrative review and meta-analysis for human studies; narrative review for animal studies.
Conclusions:
- Evidence streams will be evaluated separately and integrated.
- The review aims to strengthen the scientific basis for lead exposure reduction policies.
- This work will inform global strategies to mitigate lead's impact on behavior.
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