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Related Concept Videos

Ion Exchange01:17

Ion Exchange

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Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
642

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Solid Xenon Carrier Based on α-Cyclodextrin: Properties, Preparation, and Application.

Dmitry A Prokhorov1, Victor P Kutyshenko1, Yury S Tarahovsky1

  • 1Institute of Theoretical and Experimental Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia; Institute of Cell Biophysics, RAS, Pushchino, Moscow Region, 142290, Russia.

Journal of Pharmaceutical Sciences
|August 22, 2022
PubMed
Summary

A novel solid xenon (Xe) carrier using alpha-cyclodextrin (α-CD) allows for oral administration. This stable, lyophilized complex releases Xe upon contact with water, offering new therapeutic possibilities.

Keywords:
ComplexationCyclodextrinDehydrationInhalationLyophilizationNuclear Magnetic Resonance (NMR) spectroscopyOral administrationOral drug deliveryPhysical stabilityTransporter(s)

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Area of Science:

  • Pharmacology
  • Materials Science
  • Inorganic Chemistry

Background:

  • Inert gas xenon (Xe) has established medical applications as an anesthetic, metabolic regulator, and organoprotector.
  • Current Xe administration methods, primarily inhalation, necessitate specialized and costly equipment, limiting widespread clinical use.
  • There is a need for alternative, more accessible methods for delivering xenon therapeutically.

Purpose of the Study:

  • To develop a stable, solid carrier for oral xenon (Xe) administration.
  • To characterize the physical properties of a novel alpha-cyclodextrin (α-CD)-based Xe complex for storage and delivery.
  • To evaluate the feasibility of oral administration of this Xe complex.

Main Methods:

  • Formation of an alpha-cyclodextrin-xenon (α-CD-Xe) complex via interaction in aqueous solution under elevated pressure.
  • Stabilization of the complex through vacuum freeze-drying (lyophilization) to remove water.
  • Assessment of complex stability at room temperature and Xe release upon rehydration.
  • In vivo evaluation using the forced swim test in rats following oral administration.

Main Results:

  • A stable, solid α-CD-Xe complex was successfully produced and characterized.
  • The lyophilized complex demonstrated stability for months at room temperature and rapid Xe release upon rehydration.
  • Oral administration of the lyophilized α-CD-Xe complex in rats significantly increased swimming duration, indicating potential therapeutic effects.

Conclusions:

  • The developed lyophilized α-CD-Xe complex offers a stable and orally administrable form of xenon.
  • This novel formulation overcomes the limitations of traditional Xe inhalation methods.
  • The findings support the development of Xe-based therapeutics suitable for storage, transport, and out-of-hospital medical use.