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Fatty acid-binding protein 4 in kidney diseases: From mechanisms to clinics

Weijing Lai1, Min Shi2, Rongshuang Huang2

  • 1Kidney Research Institute, Department of Nephrology, West China Hospital of Sichuan University, Sichuan, Chengdu, 610041, China; Department of Nephrology, Clinical Medical College and the First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500, China.

European Journal of Pharmacology
|August 22, 2022
PubMed

Insights

Fatty acid-binding protein 4 (FABP4) plays a key role in kidney diseases by regulating inflammation and cell stress. Targeting FABP4 shows promise for treating kidney injury and improving patient outcomes.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Biochemistry

Background:

  • Fatty acid-binding protein 4 (FABP4) is implicated in various kidney diseases.
  • FABP4 regulates critical cellular processes including fatty acid oxidation, inflammation, apoptosis, and endoplasmic reticulum stress.
  • FABP4 influences macrophage-to-myofibroblast transition within the kidney.

Purpose of the Study:

  • To review and update the understanding of FABP4's mechanisms in kidney diseases.
  • To summarize the clinical significance of FABP4 in kidney disease progression and outcomes.
  • To highlight FABP4 as a potential therapeutic target for renal pathologies.

Main Methods:

  • Literature review of existing studies on FABP4 and kidney diseases.
  • Analysis of experimental models demonstrating FABP4's role in renal injury.
  • Synthesis of clinical data linking FABP4 levels to disease severity and prognosis.

Main Results:

  • Elevated circulating FABP4 levels correlate with proteinuria and declining renal function.
  • FABP4 is associated with cardiovascular complications in end-stage renal disease.
  • FABP4 inhibition in experimental models significantly attenuates kidney injury.

Conclusions:

  • FABP4 is a significant mediator of kidney disease pathogenesis.
  • Circulating FABP4 levels serve as a biomarker for kidney disease severity and prognosis.
  • Targeting FABP4 offers a promising therapeutic avenue for kidney diseases.
Keywords:
BiomarkerFABP4Kidney diseasesTherapeutic target

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