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Updated: Aug 31, 2025

Technique for Intranasal Administration of α-Synuclein Aggregates
Published on: November 8, 2024
Spreading of alpha-synuclein between different cell types
Wolfgang P Ruf1, Joao L Meirelles2, Karin M Danzer3
1Department of Neurology, University Clinic, University of Ulm, Ulm, Germany.
Abstract:
Aggregation of alpha-synuclein (α-syn) is central in Parkinson's disease as well as in other synucleinopathies. Recent evidence suggests that not only intracellular aggregation of α-syn plays an important role for disease pathogenesis but also cell-to-cell propagation of α-syn seems to significantly contribute to pathological changes in synucleinopathies. In this mini-review we summarize current aspects of spreading of α-syn between brain cell types and its role in pathology.
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