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Night Shift Work, Genetic Risk, and Hypertension
Zhihao Xiao1, Cheng Xu1, Qian Liu2
1State Key Laboratory of Reproductive Medicine, School of Public Health, Nanjing Medical University, Nanjing, China; Key Laboratory of Modern Toxicology of Ministry of Education, Center for Global Health, Nanjing Medical University, Nanjing, China.
Mayo Clinic Proceedings
|August 22, 2022
Summary
Night shift work increases hypertension risk, especially for those genetically predisposed. This study highlights a combined effect of shift work and genetic susceptibility on developing hypertension.
Area of Science:
- Epidemiology
- Occupational Health
- Cardiovascular Disease Research
Background:
- Limited evidence exists on the link between night shift work and hypertension.
- Genetic factors may influence hypertension risk, but their interaction with shift work is unclear.
Purpose of the Study:
- To investigate the association between night shift work and incident hypertension.
- To determine if genetic susceptibility modifies the night shift work-hypertension relationship.
Main Methods:
- Prospective cohort study of 232,665 UK Biobank participants (2006-2018).
- Cox proportional hazards models used to assess night shift work exposure and hypertension risk.
- Polygenic risk score (PRS) constructed to evaluate genetic susceptibility and its interaction with shift work.
Main Results:
- Night shift workers exhibited higher hypertension risk compared to day workers, with risk increasing with frequency.
- The association remained significant after full adjustment.
- Individuals with high PRS and permanent night shift work showed the highest hypertension risk.
Conclusions:
- Night shift work is associated with an elevated risk of developing hypertension.
- Genetic predisposition significantly modifies the impact of night shift work on hypertension.
- A joint effect exists between night shift work and genetic risk factors for hypertension.
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