Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.1K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.1K
Ribosome Profiling02:24

Ribosome Profiling

3.6K
Ribosome profiling or ribo-sequencing is a deep sequencing technique that produces a snapshot of active translation in a cell. It selectively sequences the mRNAs protected by ribosomes to get an insight into a cell’s translation landscape at any given point in time.
Applications of ribosome profiling
Ribosome profiling has many applications, including in vivo monitoring of translation inside a particular organ or tissue type and quantifying new protein synthesis levels.
The technique...
3.6K
Genome Size and the Evolution of New Genes03:21

Genome Size and the Evolution of New Genes

2.6K
2.6K
Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

4.1K
Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
Although the genome of each species varies greatly from each other, a few sequences are highly conserved. Such conserved...
4.1K
Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

47.6K
Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
47.6K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

17.9K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
17.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pangenome-based structural variant imputation enables large-scale genotype-phenotype studies in dairy cattle.

Nature communications·2026
Same author

An Adaptive Multi-Scale Manifold Embedding Preprocessing Framework for High-Dimensional Data Visualization.

IEEE transactions on visualization and computer graphics·2026
Same author

Interpretable scRNA-seq Analysis with Intelligent Gene Selection.

Applied biochemistry and biotechnology·2026
Same author

Survival prediction in stage II/III rectal cancer: Role of immune-inflammatory biomarkers post neoadjuvant chemoradiotherapy.

Oncology letters·2026
Same author

Phenotypic and genomic study of digital dermatitis in UK Holstein heifers.

BMC genomics·2026
Same author

Porcine epidemic diarrhea virus suppresses DHX9-mediated antiviral transcription through its nucleocapsid protein.

Communications biology·2026
Same journal

UK Biobank whole-genome sequencing reveals robust contributions of rare variants to complex-trait heritability.

Genome biology·2026
Same journal

A one-week automated genome-wide optical pooled screen using OttoSeq.

Genome biology·2026
Same journal

Integrated lipidomic and transcriptomic profiling of the host response in human malaria.

Genome biology·2026
Same journal

Centromeric satellite expansion drives genome evolution in the snowy owl.

Genome biology·2026
Same journal

Mapping the landscape of allele-specific expression in porcine genomes.

Genome biology·2026
Same journal

Genomic sequence evolution underlying human neocortical interareal diversification.

Genome biology·2026
See all related articles

Related Experiment Video

Updated: Aug 31, 2025

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
09:04

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Published on: January 30, 2017

7.9K

Comparative transcriptome in large-scale human and cattle populations.

Yuelin Yao1,2, Shuli Liu3,4, Charley Xia5,6

  • 1MRC Human Genetics Unit at the Institute of Genetics and Cancer, The University of Edinburgh, EH4 2XU, Edinburgh, UK.

Genome Biology
|August 22, 2022
PubMed
Summary
This summary is machine-generated.

Comparing human and cattle transcriptomes reveals conserved gene expression patterns crucial for understanding complex traits. This cross-species analysis highlights the evolutionary basis of heritability in both humans and cattle.

Keywords:
Comparative transcriptomeGene co-expressionHeritability enrichmentInter-individual variabilityRNA-seq

More Related Videos

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
12:53

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

Published on: May 19, 2018

27.2K
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.5K

Related Experiment Videos

Last Updated: Aug 31, 2025

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform
09:04

Transcriptome Profiling of In-Vivo Produced Bovine Pre-implantation Embryos Using Two-color Microarray Platform

Published on: January 30, 2017

7.9K
Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
12:53

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

Published on: May 19, 2018

27.2K
Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood
09:40

Identification of Coding and Non-coding RNA Classes Expressed in Swine Whole Blood

Published on: November 28, 2018

7.5K

Area of Science:

  • Comparative genomics
  • Evolutionary biology
  • Transcriptomics

Background:

  • Cross-species transcriptome comparisons are vital for understanding evolutionary mechanisms of phenotypic variation.
  • Previous studies were limited by small sample sizes and model organisms.

Purpose of the Study:

  • To systematically compare transcriptomes of humans and cattle across common tissues.
  • To investigate the conservation of gene expression patterns and their relationship to complex traits.

Main Methods:

  • Analysis of 10,830 human and 4,866 cattle RNA-seq samples across 20 tissues.
  • Focus on 17,315 orthologous genes.
  • Examination of genome-wide association studies for human and cattle traits.

Main Results:

  • Mean/median gene expression, expression variation, expression quantitative trait loci, and gene co-expression networks are conserved between humans and cattle.
  • Heritability of complex traits is significantly enriched in transcriptionally conserved genes.
  • Identified conserved and diverged genes across tissues.

Conclusions:

  • Provides a comprehensive transcriptomic comparison between humans and cattle.
  • Aids in deciphering the genetic and evolutionary basis of complex traits in both species.
  • Highlights the importance of conserved transcriptional mechanisms in trait heritability.