Related Experiment Video
Updated: Aug 31, 2025
Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
Published on: October 27, 2023
Anti-Toxoplasma gondii Activity of Curcumin: A Systematic Review of Pre-clinical Studies
Hamed Kalani1, Pegah Shakib2, Roghiyeh Faridnia3
1Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Objective:
This study has focused on anti-Toxoplasma gondii activity of curcumin.
Methods:
In this systematic review, anti-parasitic activity of Curcuma longa on Toxoplasma gondii was assessed. Therefore, several databases, including PubMed, Scopus, Web of Science, Embase and Google Scholar, were searched from 2010 to 2020.
Results:
Of the 2200 papers retrieved between 2010 and 2020, six articles were reliable and were scrutinized. In 2 in vitro studies, the most used strain was the RH strain of Toxoplasma gondii, whereas among 4 in vivo studies, RH strain was found in 2 (50%) studies, Me49 strain in 1(25%) study, and RH and Me49 strain in 1 (25%) study. In four in vivo studies, the most used animal model was BALB/c, and Swiss albino was found in 1 study (25%) and Albino rats in 1 study (25%).
Conclusion:
Curcumin and nanoparticles formulated with curcumin are new and useful agents for the treatment of parasitic diseases and reduction of drug resistance. The success of this therapeutic approach stems from the specific action of Curcuma longa against parasites and pathogens.
