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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

185
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
185
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

983
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
983
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

254
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
254
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

404
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
404

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Related Experiment Video

Updated: Aug 31, 2025

Formulation and Characterization of Bioactive Agent Containing Nanodisks
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Nanoformulations - Insights Towards Characterization Techniques.

Venkateshwaran Krishnaswami1, Abimanyu Sugumaran2, Venkatesan Perumal3

  • 1Department of Pharmaceutical Technology, University College of Engineering, Anna University, BIT Campus, Tiruchirappalli, Tamil Nadu, India.

Current Drug Targets
|August 23, 2022
PubMed
Summary
This summary is machine-generated.

This review summarizes key nanocharacterization techniques for drug-loaded nanoformulations, crucial for effective cancer treatment. Understanding these methods ensures optimal nanoparticle design and performance for drug delivery.

Keywords:
EPR spectraNanocharacterizationnanomaterialnanoparticlesraman spectrazeta potential

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Area of Science:

  • Pharmaceutical Nanotechnology
  • Materials Science
  • Oncology

Background:

  • Novel nanoformulations offer superior properties over conventional drugs.
  • Nanomaterials are vital for cancer prevention, treatment, and diagnosis.
  • Understanding nanoformulation chemistry is critical for molecular and systemic behavior.

Approach:

  • This review comprehensively summarizes scattered information on nanocharacterization techniques.
  • It focuses on techniques essential for drug-loaded nanoformulations.
  • The goal is to provide a consolidated understanding of nanocharacterization methods.

Key Points:

  • Characterization techniques include particle size, zeta potential, and entrapment efficiency.
  • In vitro release studies utilize chromatographic methods (HPLC, HPTLC, LC-MS/MS).
  • Other techniques include EPR, X-ray diffraction, thermal, rheometric, and morphological analyses.

Conclusions:

  • The review offers insights into various nanocharacterization techniques and their recent updates.
  • It highlights the importance of these techniques for optimizing nanoformulations.
  • Challenges encountered in nanocharacterization are also discussed.