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Association of Vitamin D Gene Polymorphisms With HCV Infection Outcome
M Neamatallah1, M S Serria1, M El-Bendary2
1Department of Medical Biochemistry and Molecular Biology, Mansoura University, Mansoura, Egypt.
British Journal of Biomedical Science
|August 23, 2022
Summary
Vitamin D Receptor (VDR) gene variants are linked to liver cancer risk in hepatitis C virus (HCV) patients. Specific VDR SNPs may serve as biomarkers for predicting hepatocellular carcinoma (HCC) development.
Area of Science:
- Genetics
- Hepatology
- Immunology
Background:
- Vitamin D receptor (VDR) plays a role in immune modulation.
- VDR and its derivatives are implicated in various diseases, including cancer and infections.
- Hepatocellular carcinoma (HCC) is a significant complication of chronic hepatitis C virus (HCV) infection.
Purpose of the Study:
- To investigate the association between Vitamin D Receptor (VDR) single nucleotide polymorphisms (SNPs) and the risk of developing hepatocellular carcinoma (HCC) in patients with chronic hepatitis C virus (HCV) infection.
- To identify potential genetic markers for HCC risk prediction in HCV-related cirrhosis.
Main Methods:
- A cohort of 861 subjects was categorized into spontaneous viral clearance (SVC), chronic hepatic cirrhosis (CHC), and HCC groups.
- Genotyping was performed for seven VDR SNPs using real-time PCR.
- Statistical analysis was conducted to compare genotype frequencies and assess associations with HCC risk.
Main Results:
- Frequencies of six VDR SNPs (rs7970376, rs11568820, rs4516035, rs2228570, rs1544410, rs731236) were significantly different in CHC and HCC groups compared to SVC, and in HCC compared to CHC (p < 0.001).
- SNP rs7970376 showed a strong association with HCC risk (OR = 7.14, p = 0.001).
- The AGTAC haplotype of five SNPs was linked to increased risk of CHC (OR = 2.88) and HCC (OR = 1.54).
Conclusions:
- Single nucleotide polymorphisms (SNPs) in the Vitamin D Receptor (VDR) gene are associated with disease progression in HCV infection.
- Specific VDR SNPs, including rs7970376, rs11568820, rs4516035, rs2228570, rs1544410, and rs731236, may serve as valuable molecular markers for predicting HCC risk in HCV patients.
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