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Recurrent SARS-CoV-2 mutations in immunodeficient patients.

S A J Wilkinson1, Alex Richter2, Anna Casey1

  • 1Institute of Microbiology and Infection, School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK.

Virus Evolution
|August 23, 2022
PubMed
Summary

Long-term SARS-CoV-2 infections in immunocompromised patients drive viral evolution. Key mutations emerge in the spike gene, impacting ACE2 affinity and immune escape, potentially generating new variants.

Keywords:
SARS-CoV-2convergent evolutiongenomicsimmunodeficiencypersistent infectionvariant emergence

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