Unusual Tumours Hidden in Blind Eyes

Area of Science:

• Ophthalmology
• Oncology
• Pathology

Background:

• This case report details three instances of previously undiagnosed eye cancers in patients experiencing recent pain in their blind eyes.
• The study highlights the critical need for thorough investigation of painful blind eyes.

Observation:

• Case 1: A woman presented with a painful, red right eye (R/E) revealing a posterior pole mass, diagnosed as choroidal melanoma post-enucleation.
• Case 2: A young male with a traumatically blind left eye (L/E) developed pain and redness, with histopathology confirming ependymoma with vascular malformation.
• Case 3: A man experienced pain and globe shrinkage in his left eye (L/E), ultimately diagnosed with choroidal osteoma after enucleation.

Findings:

• Histopathological examination confirmed intraocular malignancies including choroidal melanoma, ependymoma with vascular malformation, and choroidal osteoma in the affected eyes.
• Diagnostic imaging, including ultrasound and other modalities, aided in identifying the masses within the posterior pole of the globe.

Implications:

• The findings underscore the importance of considering and ruling out intraocular malignancy in the differential diagnosis of a painful blind eye.
• Early detection and appropriate management of these rare neoplasms are vital for patient outcomes.