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ARDS in the time of corona: context and perspective
Norbert F Voelkel1, Harm Jan Bogaard1, Wolfgang M Kuebler2
1Department of Pulmonary Medicine, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Summary
Severe COVID-19 causes respiratory failure, with limited treatments. This perspective analyzes past acute respiratory distress syndrome (ARDS) failures and COVID-19 experiences to identify barriers and suggest new therapeutic strategies.
Area of Science:
- Pulmonology and Infectious Diseases
- Critical Care Medicine
Background:
- Severe COVID-19, caused by SARS-CoV-2, frequently leads to acute respiratory distress syndrome (ARDS), a major cause of mortality.
- Despite over two years of the pandemic, effective therapies for SARS-CoV-2-induced respiratory failure remain limited.
Discussion:
- Previous research in ARDS and COVID-19 highlights significant conceptual and therapeutic barriers.
- Analysis of both successes and failures in ARDS management provides crucial insights into the challenges of treating severe respiratory illness.
Key Insights:
- Conceptual barriers have impeded therapeutic breakthroughs for severe COVID-19 and ARDS.
- Understanding these barriers is essential for developing novel treatment strategies.
Outlook:
- Exploring new avenues of thinking is critical for advancing therapy.
- Future research should focus on overcoming identified conceptual hurdles to improve patient outcomes in respiratory failure.
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