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Related Concept Videos

Anchoring Junctions01:03

Anchoring Junctions

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Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
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Cable: Problem Solving01:29

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When dealing with a cable that is fixed to two supports and subjected to uniform loading, it is crucial to determine the maximum tension in the cable. This process can be broken down into several key steps, as outlined below:
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Angle of Twist: Problem Solving01:13

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An electric motor applies a torque of 700 N·m to an aluminum shaft, triggering a stable rotation. Two pulleys, B and C, are subjected to torques of 300 N·m and 400 N·m, respectively. The modulus of rigidity is provided as 25 GPa. With the knowledge of the length and diameter of each segment, the twist angle between the two pulleys can be computed. First, a section cut is made between pulleys B and C, and the cut cross-section is analyzed using a free-body diagram. Given that the...
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Problem-Solving: Tuning of a Guitar String01:04

Problem-Solving: Tuning of a Guitar String

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In the case of stringed instruments like the guitar, the elastic property that determines the speed of the sound produced is its linear mass density or the mass per unit length. This is simply called the linear density. If the string's linear density is constant along the string, then the linear density is simply the total mass divided by the total length.
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Torsional Pendulum01:09

Torsional Pendulum

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A torsional pendulum involves the oscillation of a rigid body in which the restoring force is provided by the torsion in the string from which the rigid body is suspended. Ideally, the string should be massless; practically, its mass is much smaller than the rigid body's mass and is neglected.
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Simple Pendulum01:10

Simple Pendulum

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A simple pendulum consists of a small diameter ball suspended from a string, which has negligible mass but is strong enough to not stretch. In our daily life, pendulums have many uses, such as in clocks, on a swing set, and on a sinker on a fishing line. 
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Updated: Aug 31, 2025

Single-molecule Manipulation of G-quadruplexes by Magnetic Tweezers
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ALSUntangled #65: glucocorticoid corticosteroids.

Jill Ann Goslinga1, Mark Terrelonge1, Richard Bedlack2

  • 1Neurology Department, University of California San Francisco, San Francisco, CA, USA.

Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
|August 23, 2022
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This summary is machine-generated.

Glucocorticoids are not recommended for treating amyotrophic lateral sclerosis (ALS). Evidence shows they do not provide clinical benefits and carry significant risks for people with ALS.

Keywords:
Amyotrophic lateral sclerosis (ALS)SOD1alternative therapyexcitotoxicityglucocorticoidsneuroinflammationneuropathologysteroids

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Area of Science:

  • Neurology
  • Immunology

Background:

  • Neuroinflammation is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS).
  • Glucocorticoids possess immunosuppressive properties, leading to hypotheses about their potential therapeutic efficacy in ALS.

Conclusions:

  • Current evidence suggests that glucocorticoids do not offer clinical benefits for patients with amyotrophic lateral sclerosis (ALS).
  • The use of glucocorticoids in ALS treatment is associated with significant risks, outweighing any potential benefits.
  • ALSUntangled advises against the use of glucocorticoids for treating ALS based on the reviewed evidence.