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Related Concept Videos

Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

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Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
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Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
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Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
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Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Related Experiment Video

Updated: Aug 31, 2025

Animal Models of Depression - Chronic Despair Model CDM
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Animal Models of Depression - Chronic Despair Model CDM

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Innate depression.

Leslie K Ferrarelli1

  • 1Science Signaling, AAAS, Washington, DC 20005, USA.

Science Signaling
|August 23, 2022
PubMed
Summary

Restoring the AHI1 protein in macrophages could enhance antiviral defenses in individuals experiencing depression. This finding offers a potential new avenue for improving immune function in this patient population.

Area of Science:

  • Immunology
  • Neuroscience
  • Molecular Biology

Background:

  • Depression is linked to impaired immune responses.
  • The protein AHI1 plays a role in immune cell function.
  • Macrophage dysfunction may contribute to altered immunity in depression.

Purpose of the Study:

  • To investigate the role of AHI1 in macrophage antiviral immunity.
  • To determine if restoring AHI1 levels can improve immune function in a depression context.

Main Methods:

  • Utilized macrophage cell models.
  • Manipulated AHI1 expression levels.
  • Assessed antiviral immune responses.

Main Results:

  • Restoring AHI1 in macrophages enhanced their ability to combat viral infections.

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  • AHI1 appears crucial for effective macrophage-mediated antiviral immunity.

    • Conclusions:

    • Targeting AHI1 in macrophages presents a potential therapeutic strategy for enhancing antiviral immunity in patients with depression.