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Targeted therapy in Coronavirus disease 2019 (COVID-19): Implication from cell and gene therapy to immunotherapy and

Moein Shirzad1, Marjan Nourigorji1, Atefe Sajedi2

  • 1Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.

International Immunopharmacology
|August 23, 2022
PubMed

Insights

This review summarizes treatments for Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2. It covers traditional therapies and explores promising novel approaches like gene editing and immunotherapy for effective COVID-19 treatment.

Area of Science:

  • Virology and Infectious Diseases
  • Immunology
  • Genetics

Background:

  • Severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) causes COVID-19, a severe respiratory illness particularly dangerous for high-risk individuals.
  • COVID-19 presents with severe respiratory distress, hyperinflammation, vascular damage, and thrombosis.
  • Current treatment strategies for COVID-19 are diverse, ranging from supportive care to vaccines, with varied patient outcomes.

Purpose of the Study:

  • To review and summarize various treatment strategies for COVID-19.
  • To provide an overview of both established and emerging therapeutic approaches.

Main Methods:

  • Literature review of in vitro and in vivo studies on COVID-19 treatments.
  • Analysis of traditional and novel therapeutic methods.

Main Results:

  • A wide array of treatments, including oxygen therapy, corticosteroids, and antivirals, have been investigated.
  • Novel approaches such as gene editing, cell-based therapy, and immunotherapy show significant potential for treating COVID-19.

Conclusions:

  • No single approved therapeutic option exists for COVID-19.
  • Emerging therapies like gene editing, cell-based therapy, and immunotherapy offer promising avenues for future COVID-19 treatment development.
Keywords:
Cell based therapyCoronavirusImmunotherapyVaccine

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