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Published on: October 3, 2018
Oxygen heterocyclic Diels-Alder-Type sesquiterpenoid dimers from Vernonia anthelmintica
Ablajan Turak1, Haji Akber Aisa1
1State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, and the Key Laboratory of Plant Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China.
Abstract:
Eleven undescribed oxygen heterocyclic Diels-Alder-Type sesquiterpenoid dimers, vernodalidimer I-K and M-T, along with a known one, vernodalidimer B were isolated from the seeds of Vernonia anthelmintica. The structures of them were elucidated based on 1D, 2D-NMR experiments and HRESIMS. The absolute configurations of vernodalidimer I-K and M-T were determined by comparison of their experimental and calculated electronic circular dichroism spectra. Cytotoxicity of the isolates against HCT-15, PC-3, A549, and HeLa cell lines were tested. Vernodalidimer K and Q exhibited significant cytotoxic activity against HCT-15 cell line with IC50 values of 9.8 ± 5.4 μM and 9.4 ± 1.3 μM, respectively.
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