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Updated: Aug 31, 2025
Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures
Published on: January 6, 2010
Automatic oxygen control for reducing extremes of oxygen saturation: a randomised controlled trial
Vrinda Nair1,2, Prakash Kannan Loganathan3, Mithilesh Kumar Lal4
1Neonatology, James Cook University Hospital, Middlesbrough, UK vrinda.nair1@nhs.net.
Objective:
The objective of this study was to evaluate the efficacy of the automatic oxygen control (A-Fio2) in reducing the percentage of time spent in severe hypoxaemia (Spo2 <80%) in preterm infants for the time period on invasive ventilation and/or nasal continuous positive airway pressure (NCPAP) delivered by AVEA ventilator.
Design:
A parallel arm randomised controlled trial.
Setting:
A level-III neonatal intensive care unit.
Patients:
Preterm infants (<33 weeks birth gestation) who received invasive ventilation or NCPAP in the first 72 hours of age.
Interventions:
A-Fio2 vs manual (M-Fio2) oxygen control.
Outcomes:
The primary outcome of the study was percentage of time spent in severe hypoxaemia (Spo2 <80%).
Results:
44 infants were randomised to either A-Fio2 or M-Fio2 arm and continued in the study for the period of respiratory support (invasive ventilation and/or NCPAP). The total number of study days in A-Fio2 and M-Fio2 arm were 194 and 204 days, respectively. The percentage of time spent in Spo2 <80% was significantly lower with A-Fio2 compared with M-Fio2 (median of 0.1% (IQR: 0.07-0.7) vs 0.6% (0.2-2); p=0.03). The number of prolonged episodes (>60 s) of Spo2 <80% per day was also significantly lower in A-Fio2 (0.3 (0.0-2) vs 2 (0.6-6); p=0.02).
Conclusion:
A-Fio2 was associated with statistically significant reduction in the percentage of time spent in severe hypoxaemia when compared with M-Fio2 in preterm infants receiving respiratory support.
Trial Registration Number:
NCT04223258.
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