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A CRISPR/Cas9 engineered MplS504N mouse model recapitulates human myelofibrosis

Fabienne R S Adriaanse1,2, Jennifer L Kamens3, Peter Vogel4

  • 1Department of Pediatric Oncology, Erasmus MC-Sophia's Children's Hospital, Rotterdam, The Netherlands.

Leukemia
|August 23, 2022
PubMed
Abstract

No abstract available in PubMed .

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...