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Metal-organic framework MIL-100(Fe) as a promising sensor for COVID-19 biomarkers detection
Nuttapon Yodsin1, Kunlanat Sriphumrat2, Poobodin Mano1
1National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, 12120, Thailand.
Microporous and Mesoporous Materials : the Official Journal of the International Zeolite Association
|August 24, 2022
Summary
Metal-organic frameworks (MOFs) show promise for detecting COVID-19 biomarkers in breath. MIL-100(Fe) demonstrated high sensitivity and selectivity for specific biomarkers, suggesting its potential for rapid, non-invasive COVID-19 detection.
Area of Science:
- Materials Science
- Chemistry
- Nanotechnology
- Biomedical Engineering
Background:
- Early detection of SARS-CoV-2 is crucial for controlling the COVID-19 pandemic.
- Fast, non-invasive diagnostic techniques are highly desirable.
- Metal-organic frameworks (MOFs) offer tunable porous structures for selective sensing.
Purpose of the Study:
- To investigate the potential of MOFs for detecting COVID-19 biomarkers.
- To evaluate MIL-100(Al) and MIL-100(Fe) MOFs for sensing specific biomarkers in exhaled breath.
- To explore MOF-biomarker interactions using computational and experimental methods.
Main Methods:
- Density Functional Theory (DFT) calculations to study MOF-biomarker interactions.
- Comparative analysis of MIL-100(Al) and MIL-100(Fe) with five dominant COVID-19 biomarkers and common exhaled gases.
- Experimental validation of MOF sensitivity towards specific biomarkers.
Main Results:
- MIL-100(Fe) exhibited superior sensitivity and selectivity compared to MIL-100(Al).
- MIL-100(Fe) showed exceptionally high sensing responses to 2-methylpent-2-enal and 2,4-octadiene.
- Calculated short recovery times indicate potential for reusable sensor applications; experimental results confirmed sensitivity to 2-methylpent-2-enal.
Conclusions:
- MIL-100(Fe) is a promising candidate for developing sensors for exhaled breath analysis.
- This research supports the development of rapid, non-invasive biosensors for COVID-19 detection.
- The findings contribute to controlling the COVID-19 pandemic through improved diagnostic tools.
