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Updated: Aug 31, 2025
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An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
An improved radiosynthesis of [18 F]FAraG, a PET radiotracer for imaging T-cell activation
Daniel P Holt1, Robert F Dannals1
1Division of Nuclear Medicine, Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Abstract:
In this concise practitioner protocol, the radiochemical synthesis of 2'-deoxy-2'-[18 F]fluoro-9-β-d-arabinofuranosylguanine ([18 F]FAraG) suitable for human positron emission tomography (PET) studies is described and the results from validation productions are presented. The high specific activity (sometimes referred to as molar activity) radiotracer product is prepared as a sterile, apyrogenic solution that conforms to current Good Manufacturing Practice (cGMP) requirements established by the U.S. Food and Drug Administration.
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