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FIND-IT: Accelerated trait development for a green evolution.

Søren Knudsen1, Toni Wendt1, Christoph Dockter1

  • 1Carlsberg Research Laboratory, J.C. Jacobsens Gade 4, DK-1799 Copenhagen V, Denmark.

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|August 24, 2022
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This summary is machine-generated.

A new method, Fast Identification of Nucleotide variants by droplet DigITal PCR (FIND-IT), rapidly identifies genetic variants in crops. This accelerates the development of improved agricultural organisms to meet global food demands.

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Area of Science:

  • Agricultural Science
  • Genetics
  • Biotechnology

Background:

  • Global food security and climate change necessitate improved agricultural and industrial organisms.
  • Efficient methods for identifying genetic variants are crucial for crop and microbe improvement.

Purpose of the Study:

  • To introduce FIND-IT (Fast Identification of Nucleotide variants by droplet DigITal PCR), a novel resource for ultrafast genetic variant identification and isolation.
  • To demonstrate the application of FIND-IT in accelerating crop improvement pipelines.

Main Methods:

  • Utilizes large-scale sample pooling combined with droplet digital PCR (ddPCR).
  • Enables screening of large variant libraries with low-mutation densities.
  • Achieves identification and isolation of targeted genetic variants in under 10 days.

Main Results:

  • Successfully screened 500,000 barley (Hordeum vulgare) individuals.
  • Isolated over 125 targeted barley gene knockout lines and miRNA or promoter variants.
  • Demonstrated the applicability of FIND-IT to elite breeding pipelines.

Conclusions:

  • FIND-IT significantly accelerates the identification and isolation of genetic variants.
  • The method reduces time-consuming technical steps, speeding up germplasm evolution.
  • FIND-IT is a valuable tool for developing improved agricultural organisms to address global challenges.