Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain amino acids decrease in chronic hyponatremia and rapid correction causes brain dehydration: possible clinical

J H Thurston, R E Hauhart

    Life Sciences
    |June 29, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.

    Blood·2001
    Same author

    Decay accelerating activity of complement receptor type 1 (CD35). Two active sites are required for dissociating C5 convertases.

    The Journal of biological chemistry·1999
    Same author

    Comparative effects of valproate and the new experimental anticonvulsant drug alpha-ethyl-alpha-methyl-thiobutyrolactone on selected metabolite levels in the plasma, livers, and brains of infant mice.

    Epilepsia·1996
    Same author

    Glycerol treatment in bacterial meningitis.

    The Pediatric infectious disease journal·1996
    Same author

    Developmental and neurologic status of children after heart surgery.

    The New England journal of medicine·1995
    Same author

    Effects of acute, subacute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve. Relation to mechanisms of peripheral neuropathy.

    Diabetes·1995
    Same journal

    Corrigendum to "Adipose stem cells-derived microvesicles and chicken egg-derived exosomes attenuate cardiac ischemia/reperfusion injury through AKT/ERK/Nrf2/HO-1 axis to inhibit apoptosis and inflammation and restore autophagy" [Life Sci. 395 (2026) 124364].

    Life sciences·2026
    Same journal

    MAGED1 stabilizes NEUROD1 to promote Per3 expression in the pineal gland.

    Life sciences·2026
    Same journal

    TNF-centered network pharmacology and molecular modeling of selected Andrographis paniculata compounds in hypertension.

    Life sciences·2026
    Same journal

    Retraction notice to "Beneficial effect of Calculus Bovis Sativus on 17α-ethynylestradiol-induced cholestasis in the rat" [Life Sci. 113 (2014) 22-30].

    Life sciences·2026
    Same journal

    Soluble PD-1 drives renal fibrosis in CKD by disrupting immune homeostasis: Therapeutic mitigation via a targeted sPD-1 sequestration strategy.

    Life sciences·2026
    Same journal

    METTL1 promotes hepatic steatosis by mediating m<sup>7</sup>G modification of ALOX15B mRNA.

    Life sciences·2026
    See all related articles

    Rapid correction of chronic hyponatremia in young mice caused brain dehydration and lesions. This highlights the need for caution when raising low plasma sodium levels to prevent osmotic damage.

    Area of Science:

    • Neuroscience
    • Physiology
    • Biochemistry

    Background:

    • Rapid correction of chronic hyponatremia in animals can lead to brain lesions, similar to central pontine myelinolysis.
    • Understanding the impact on brain composition during correction is crucial for preventing neurological damage.

    Purpose of the Study:

    • To investigate the effects of rapid correction of chronic hyponatremia on brain electrolyte, water, and amino acid content in young mice.
    • To elucidate the osmotic and biochemical changes in the brain during rapid hyponatremia correction.

    Main Methods:

    • Induction of chronic hyponatremia (3 days) in young mice.
    • Rapid correction of hyponatremia over 9 hours.
    • Analysis of brain electrolyte, water, and amino acid concentrations.

    Related Experiment Videos

    Main Results:

    • Despite profound hyponatremia, brain electrolytes and amino acids decreased, maintaining apparent osmotic balance with normal brain water content.
    • Rapid correction led to brain dehydration, with Na+ and K+ returning to normal but insufficient recovery of amino acid levels.
    • Evidence of osmotic disequilibrium (plasma osmolality > brain osmolality) during rapid correction.

    Conclusions:

    • Rapid correction of chronic hyponatremia causes brain dehydration and osmotic disequilibrium.
    • Incomplete recovery of brain amino acid levels suggests ongoing cellular stress.
    • Caution is advised regarding the rate of plasma sodium elevation in hyponatremic patients to prevent brain lesions.