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Updated: Aug 31, 2025

Bioinspired Soft Robot with Incorporated Microelectrodes
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Will microfluidics enable functionally integrated biohybrid robots?

Miriam Filippi1, Oncay Yasa1, Roger Dale Kamm2,3

  • 1Soft Robotics Laboratory, Department of Mechanical Engineering, Eidgenossische Technische Hochschule Zurich, 8092 Zurich, Switzerland.

Proceedings of the National Academy of Sciences of the United States of America
|August 24, 2022
PubMed
Summary
This summary is machine-generated.

Biohybrid robots, merging biology and engineering, will advance robotics. Microfluidics integration is key for developing complex living tissues, enhancing biohybrid capabilities for future innovations.

Keywords:
bioactuatorsbiohybrid roboticsmicrofluidicssoft roboticstissue engineering

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Area of Science:

  • Robotics and Bioengineering
  • Biotechnology and Tissue Engineering
  • Microfluidics and Living Materials

Background:

  • The future of robotics lies in biohybrid systems, which integrate biological components with artificial structures.
  • Microfluidics technology has significantly impacted disease modeling and drug discovery.
  • Current microfluidic applications have not yet been extensively applied to the development of biohybrid robots.

Purpose of the Study:

  • To highlight the critical role of microfluidics in advancing biohybrid robot development.
  • To explore the potential of integrating microfluidics with living biological tissues for enhanced robotic systems.
  • To outline future directions for sophisticated biohybrid robots.

Main Methods:

  • Conceptual analysis of microfluidics applications in biological systems.
  • Review of current advancements in tissue engineering and microfluidic devices.
  • Perspective on the fusion of microfluidics with living materials for robotic applications.

Main Results:

  • Microfluidics can sustain, improve, and scale the complexity of biological tissues used in biohybrids.
  • Integration of microfluidics enhances tissue perfusion and maturation.
  • Enables precise patterning of sensing, processing, and control elements within biohybrid systems.

Conclusions:

  • The fusion of microfluidics and living materials is essential for the next generation of biohybrid robots.
  • This integration promises to improve the functionality and capabilities of biohybrid systems.
  • Advanced biohybrid robots hold significant potential for future technological advancements.