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Suncus murinus: a new experimental model in emesis research.

S Ueno, N Matsuki, H Saito

    Life Sciences
    |July 27, 1987
    PubMed
    Summary

    The Suncus murinus effectively models emesis, responding to various emetic drugs like nicotine and copper sulfate. This animal model shows sensitivity to antiemetic drugs, proving useful for emesis research.

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    Area of Science:

    • Pharmacology
    • Toxicology
    • Animal Models

    Background:

    • Emesis research requires suitable animal models.
    • The Suncus murinus (suncus) has not been extensively studied for its emetic responses.

    Purpose of the Study:

    • To evaluate the Suncus murinus as a potential animal model for emesis research.
    • To investigate the effects of various emetic and antiemetic drugs on suncus.

    Main Methods:

    • Administered various emetic agents subcutaneously (nicotine bitartrate, veratrine sulfate, emetine dihydrochloride) and orally (copper sulfate, emetine dihydrochloride).
    • Tested antiemetic drugs (chlorpromazine, promethazine, scopolamine hydrobromide) against emetic agents.
    • Determined the ED50 (effective dose for 50% of subjects) for emetic drugs.

    Main Results:

    • Nicotine, veratrine, emetine, and copper sulfate induced dose-dependent emesis in suncus.
    • Apomorphine and digitoxin did not induce vomiting.
    • Chlorpromazine and promethazine reduced emetic effects; scopolamine was ineffective.
    • Established ED50 values for effective emetic agents.

    Conclusions:

    • Suncus murinus is a sensitive and viable animal model for emesis research.
    • The model responds predictably to various emetic and antiemetic drugs.
    • Further comparative studies of emetic behavior in suncus are warranted.

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