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Risk Factors for Glaucoma Drainage Device Exposure in Children: A Case-Control Study
Deema E Jomar1, Sami Al-Shahwan1, Ali S Al-Beishri1
1From the Glaucoma Division, King Khaled Eye Specialist Hospital (D.E.J., S.A.-S., A.S.A.-B., R.M.), Riyadh, Saudi Arabia.
Insights
Younger age, combined procedures, and multiple prior surgeries increase glaucoma drainage device exposure risk in children. Postoperative eye lubricants may offer protection against this complication.
Area of Science:
- Ophthalmology
- Pediatric Glaucoma Management
- Surgical Complications
Background:
- Glaucoma drainage devices (GDDs) are used to manage pediatric glaucoma.
- Device exposure is a significant complication, potentially leading to further vision loss.
- Identifying risk factors is crucial for preventing GDD exposure in children.
Purpose of the Study:
- To determine the risk factors associated with glaucoma drainage device (GDD) exposure in pediatric patients.
- To analyze factors contributing to GDD exposure in children under 18 years old.
Main Methods:
- Retrospective case-control study including children with and without GDD exposure.
- Data collected from a tertiary care eye hospital between January 2014 and January 2020.
- Univariate and multivariate analyses were performed to identify risk factors.
Main Results:
- An estimated 4.25% incidence of GDD exposure was observed.
- Risk factors for exposure included multiple previous ocular surgeries, longer follow-up, combined procedures during primary implantation, and younger age at implantation.
- Postoperative eye lubricant use was more frequent in the control group (no exposure).
Conclusions:
- Younger age at primary GDD implantation, combined procedures, and multiple prior ocular surgeries are significant risk factors for GDD exposure in pediatric glaucoma.
- The use of postoperative eye lubricants may be a protective factor against GDD exposure.
Purpose:
To identify the risk factors for glaucoma drainage device (GDD) exposure in children.
Design:
Retrospective case-control study.
Methods:
The study population comprised children (one eye each) who presented with a history of GDD exposure to a tertiary care eye hospital over the period January 2014 to January 2020. Consecutive children (age <18 years) were included. A control group from the same time period (children without GDD exposure) were included in the ratio of 5 controls to every 1 case of exposure. The main outcome measures included risk factors for exposure (univariate and multivariate analysis).
Results:
A total of 21 eyes (of 21 children with implant exposure) and 115 eyes (of 115 children without exposure) were included in this study. During the same study period, a total of 494 eyes had undergone GDD implantation, giving an estimated incidence of exposure of 4.25%). In the bivariate analysis, GDD exposure was associated with multiple previous ocular surgeries (P = .001), longer follow-up duration (P < .001), combined procedure at the time of primary implantation (P = .002), and a younger age at the time of primary implantation (P = .006). The former 3 risk factors continued to prove a statistically significant association on multivariable regression analysis. Postoperative use of eye lubricants was more common among children in the control group (P = .007).
Conclusion:
In pediatric glaucoma patients, younger age and combined procedure at the time of primary GDD implantation, in addition to multiple previous ocular surgeries, were associated with greater risk of implant exposure. Postoperative use of eye lubricants may be protective.
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