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A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes.

Darin Salloum1, Kamini Singh1,2, Natalie R Davidson3,4,5

  • 1Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY.

Journal of Immunology (Baltimore, Md. : 1950)
|August 24, 2022
PubMed
Summary
This summary is machine-generated.

Early T cell activation relies on translating existing mRNAs, not new gene expression. This rapid RNA translation program drives CD8 memory T cell expansion and activation.

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Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • Memory T cell activation is a rapid process requiring precise cellular coordination.
  • Understanding the early molecular events in T cell activation is crucial for immune response research.

Purpose of the Study:

  • To define acute mRNA translation changes in CD8 memory T cells upon activation.
  • To investigate the role of pre-existing mRNA translation in early T cell activation.

Main Methods:

  • Ribosome profiling and deep RNA sequencing were employed.
  • Analysis focused on CD8 memory T cells from human and mouse models.

Main Results:

  • Early T cell activation events are translation-dependent, not transcription-dependent.
  • Identified approximately 92 mRNAs recruited to ribosomes, encoding key regulators like Notch1, Ifngr1, Il2rb, serine metabolism enzymes, and translation factors.
  • Increased production of IL-2 and IFN-γ receptors precedes gene activation, enhancing T cell signaling.

Conclusions:

  • An early RNA translation program facilitates rapid CD8 memory T cell expansion and activation.
  • This program operates in a feed-forward manner to amplify cellular responses.