Clinical usefulness of layer-by-layer deviation maps of Spectralis OCT: comparison with Cirrus OCT

To compare the diagnostic abilities of Spectralis (Heidelberg Engineering, Heidelberg, Germany) and Cirrus (Carl Zeiss Meditec, Dublin, California, USA) spectral domain-optical coherence tomography (OCT) for retinal nerve fibre layer (RNFL) defect detection among patients with preperimetric glaucoma (PPG) and early glaucoma (EG).

In this cross-sectional study, a total of 144 eyes (47 healthy, 43 PPG, 54 EG; MD≥-6 dB) of 144 participants underwent Spectralis and Cirrus OCT on the same day. The presence of RNFL defect on red-free RNFL photography and the respective deviation maps of Spectralis and Cirrus OCT was rated. Areas under the receiver operating characteristic curves (AUCs), sensitivities and specificities were analysed for each deviation layer to discriminate healthy eyes from PPG and EG eyes.

The RNFL, ganglion cell layer (GCL) and retinal layers of Spectralis OCT and the RNFL and macular ganglion cell-inner plexiform layer of Cirrus OCT showed high diagnostic performance (all AUCs >0.8) in discriminating PPG and EG eyes from healthy eyes. Among them, RNFL layer of Cirrus OCT had the largest AUC (0.840 for PPG, 0.959 for EG) but showed no statistical differences from RNFL and retinal layers of Spectralis OCT. The inner plexiform layer (IPL) of Spectralis OCT had the smallest AUC (0.563 for PPG, 0.799 for EG).

The Spectralis and Cirrus OCT deviation maps showed good diagnostic abilities except for the IPL layer of Spectralis. In the clinical setting, both Spectralis and Cirrus OCT can be useful for detection of RNFL defects in PPG and EG eyes.