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Related Experiment Video

Updated: Aug 31, 2025

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

COManeci MechANical Dilation for vasospasm (COMMAND): multicenter experience.

Mohamed M Salem¹, Jane Khalife², Sohum Desai³

¹Department of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, Pennsylvania, USA.

Journal of Neurointerventional Surgery

|August 24, 2022

Summary

This summary is machine-generated.

The Comaneci device effectively treats refractory intracranial vasospasm, showing significant vessel score improvement and a favorable safety profile in a large multicenter study. Further trials are recommended.

Keywords:

Hemorrhage Subarachnoid

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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology

Published on: February 7, 2015

Area of Science:

Neurology
Interventional Neuroradiology
Vascular Surgery

Background:

Refractory intracranial vasospasm poses significant risks after subarachnoid hemorrhage.
Endovascular mechanical dilatation is an emerging treatment modality.

Purpose of the Study:

To evaluate the safety and efficacy of the Comaneci device for endovascular treatment of refractory intracranial vasospasm.
To report the largest multicenter experience with this device.

Main Methods:

Retrospective analysis of prospectively maintained registries from 11 North American centers (2020-2022).
Inclusion of patients undergoing Comaneci mechanical dilatation for vasospasm, with optional intra-arterial vasodilators.
Assessment of pre- and post-treatment vasospasm scores, procedural complications, and functional outcomes.

Main Results:

129 vessels in 40 patients treated, with 84.5% having severe-to-critical vasospasm.
Significant vasospasm reduction achieved in 89.9% of treated vessels.
No major device-related complications; 51.5% of patients had favorable clinical outcomes at 6 months.

Conclusions:

The Comaneci device offers a safe and effective complementary strategy for refractory intracranial vasospasm.
The device demonstrates reasonable efficacy in improving radiological scores.
Further prospective trials are warranted to confirm these findings.