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Effects of raltegravir formulation change on medication adherence and medication errors
Sonoe Higashino1, Takeo Yasu1,2, Kenji Momo1,3
1Department of Pharmacy, The Institute of Medical Science Hospital, The University of Tokyo, Tokyo, Japan.
Drug Discoveries & Therapeutics
|August 24, 2022
Summary
Raltegravir dosing changes improved human immunodeficiency virus (HIV) treatment adherence. While generally effective, some patients required additional support to prevent incorrect drug intake with the new regimen.
Area of Science:
- Pharmacology
- Infectious Diseases
- HIV/AIDS Treatment
Background:
- Raltegravir is an integrase strand transfer inhibitor used for HIV treatment.
- Changes in drug dosing schedules can impact patient adherence and treatment outcomes.
- Assessing adherence is crucial for optimizing antiretroviral therapy.
Purpose of the Study:
- To evaluate medication adherence and identify incorrect drug intake after a raltegravir dosing schedule change.
- To compare adherence rates before and after switching from raltegravir 400 mg twice daily (BID) to 600 mg once daily (QD).
Main Methods:
- A study involving 25 male HIV-infected patients.
- Medication adherence was assessed using a 100-mm visual analog scale (VAS) and pill counts over 1 month.
- Pharmacist counseling was provided after the first post-change visit.
Main Results:
- Medication adherence significantly improved from 96 ± 4.3 mm (BID) to 100 ± 0.3 mm (QD) (P < 0.05).
- Despite overall improved adherence, three patients experienced incorrect drug intake following the formulation change.
Conclusions:
- The shift to a once-daily raltegravir regimen enhances treatment suitability and patient adherence in HIV-infected individuals.
- Close monitoring and patient education are essential to mitigate risks of incorrect drug administration associated with dosing schedule changes.
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