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Related Concept Videos

Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

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The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
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Fos ensembles encode and shape stable spatial maps in the hippocampus.

Noah L Pettit1, Ee-Lynn Yap1, Michael E Greenberg2

  • 1Department of Neurobiology, Harvard Medical School, Boston, MA, USA.

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Neurons expressing the Fos gene form stable, reliable spatial maps in the hippocampus. Fos expression causally shapes these place codes, linking memory engrams to cognitive maps.

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Molecular Neuroscience

Background:

  • Hippocampal place cells form spatial maps, while engrams encode memories.
  • Fos expression is a marker for neuronal activity but its role in spatial coding is unclear.

Purpose of the Study:

  • Investigate the relationship between Fos expression and hippocampal place codes.
  • Determine the causal role of Fos in shaping spatial maps and memory.

Main Methods:

  • Calcium imaging of CA1 neurons in mice during a virtual reality spatial task.
  • Monitoring Fos induction and using genetic loss-of-function to assess Fos's role.

Main Results:

  • Fos-expressing neurons form highly correlated ensembles with stable, uniformly distributed place fields.
  • Disrupting Fos function leads to less reliable activity, reduced spatial selectivity, and decreased stability.

Conclusions:

  • Fos-induced cells are crucial for accurate, stable hippocampal spatial maps.
  • Fos causally influences place code features, linking memory engrams with cognitive maps.