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Associations between sarcopenia with asthmatic prevalence, lung function and comorbidity.
Zhigang Hu1,2,3, Yufeng Tian4, Xinyu Song5,6
1Department of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, 443003, People's Republic of China. hxq910813@163.com.
BMC Geriatrics
|August 24, 2022
Summary
Sarcopenia, a loss of muscle mass, is linked to increased asthma severity, reduced lung function, and more comorbidities like COPD and depression. It may be a treatable trait in asthma management.
Area of Science:
- Gerontology
- Respiratory Medicine
- Public Health
Background:
- Sarcopenia is recognized as a risk factor for severe asthma, yet research on the asthma-sarcopenia link is limited.
- This study investigates the associations between sarcopenia and asthma prevalence, symptoms, lung function, and comorbidities.
Purpose of the Study:
- To determine the prevalence of sarcopenia in individuals with asthma.
- To examine the relationship between sarcopenia and asthma symptoms, including severe shortness of breath.
- To assess the impact of sarcopenia on lung function (e.g., PEF) and comorbidities in asthma patients.
Main Methods:
- Utilized data from the China Health and Retirement Longitudinal Study (CHARLS) and the Study on global AGEing and adult health (SAGE) in China.
- Included 15,404 individuals from CHARLS and 10,263 from SAGE.
- Employed generalized additive models to assess bidirectional associations and estimate relationships between sarcopenia, asthma, and related factors, defining depression using the Center for Epidemiological Studies-Depression Scale.
Main Results:
- Sarcopenia prevalence was higher in asthmatic individuals compared to non-asthmatics in both cohorts.
- Asthma patients with sarcopenia showed significantly higher rates of severe shortness of breath and airway obstruction, and reduced PEF.
- Sarcopenia was positively associated with chronic obstructive pulmonary disease (COPD) and depression in asthmatic individuals.
Conclusions:
- Sarcopenia is associated with poorer asthma outcomes, including reduced lung function and increased comorbidities.
- The findings suggest sarcopenia plays a role in asthma development and progression.
- Sarcopenia may be considered a potentially treatable trait for managing asthma.
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