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Longitudinal changes of deep gray matter shape in multiple sclerosis.

Charidimos Tsagkas1, Emanuel Geiter2, Laura Gaetano3

  • 1Neurologic Clinic and Policlinic, Departments of Medicine, Clinical Research and Biomedical Engineering, Department of Neurology, University Hospital Basel and University of Basel, Basel, Switzerland; Translational Imaging in Neurology (ThINK) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland.

Neuroimage. Clinical
|August 25, 2022
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Summary

Deep gray matter (DGM) in multiple sclerosis (MS) shows specific shape changes over time, linked to disease severity and lesion load, but not disease progression.

Keywords:
AtrophyDeep gray matterMultiple sclerosisNeurodegenerationNeuroimagingShape

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Area of Science:

  • Neuroimaging
  • Neurology
  • Medical Research

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease characterized by demyelination and axonal damage.
  • Deep gray matter (DGM) structures are affected in MS, but their longitudinal shape changes and relationship with clinical outcomes require further investigation.

Purpose of the Study:

  • To investigate longitudinal deep gray matter (DGM) shape changes in a large multiple sclerosis (MS) cohort.
  • To examine the relationship between DGM shape changes and clinical disability measures and white matter lesion load.

Main Methods:

  • Longitudinal analysis of DGM shapes using MRI in 230 MS patients over up to 6 years.
  • Correlation of DGM shape changes with clinical assessments (disability, cognitive function) and white matter lesion load.

Main Results:

  • Significant shrinkage observed in bilateral ventrolateral pallidal and left posterolateral striatal surfaces over time.
  • Higher lesion load associated with inward displacement of thalamic, striatal, and pallidal surfaces.
  • Shrinkage of DGM surfaces correlated with higher motor and cognitive disease severity.

Conclusions:

  • Specific DGM shape changes occur over time in MS, particularly in relapse-onset MS.
  • These shape changes are associated with average disease severity and white matter lesion load.
  • No correlation found between DGM shape changes over time and clinical progression or lesion load changes over time.