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Remote ischemic conditioning for acute ischemic stroke part 2: Study protocol for a randomized controlled trial
Kentaro Ishizuka1, Takao Hoshino1, Sono Toi1
1Department of Neurology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan.
Frontiers in Neurology
|August 25, 2022
Summary
Remote ischemic conditioning (RIC) may improve outcomes for stroke patients. This clinical trial investigates RIC
Area of Science:
- Neurology
- Cardiovascular Medicine
- Regenerative Medicine
Background:
- Remote ischemic conditioning (RIC) involves brief, repeated ischemia to protect distant tissues from prolonged ischemic damage.
- Ischemic stroke remains a leading cause of disability, necessitating novel therapeutic strategies.
Purpose of the Study:
- To evaluate the efficacy of RIC in improving functional outcomes for patients following ischemic stroke.
- To determine if RIC can be recommended as a standard clinical intervention for stroke patients.
Main Methods:
- A multicenter, prospective, randomized, open-label trial involving 400 patients with ischemic stroke.
- Patients were stratified into mild, moderate, and severe groups based on NIH Stroke Scale scores.
- The intervention group received four cycles of RIC using a thigh cuff, while the control group received sham intervention.
Main Results:
- The primary outcome is functional outcome measured by the modified Rankin Scale (mRS) at 90 days post-stroke.
- Specific target mRS scores (0-1 for mild, 0-2 for moderate, 0-3 for severe) define a good functional outcome.
Conclusions:
- This trial aims to provide crucial evidence on the clinical utility of RIC for ischemic stroke.
- Findings will inform guidelines regarding the adoption of RIC as a routine stroke management strategy.
