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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Glymphatic system dysfunction in patients with early chronic kidney disease
Chang Min Heo1, Dong Ah Lee2, Kang Min Park2
1Departments of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Frontiers in Neurology
|August 25, 2022
Summary
Glymphatic system dysfunction is evident in early chronic kidney disease (CKD) patients, as shown by a lower diffusion tensor image analysis along perivascular space (DTI-ALPS) index. This finding suggests a link between CKD and neurological issues, potentially impacting cognition.
Area of Science:
- Neuroscience
- Nephrology
- Radiology
Background:
- Glymphatic system dysfunction is increasingly recognized as a contributor to neurological disorders.
- Early chronic kidney disease (CKD) can affect neurological function, even in asymptomatic individuals.
Purpose of the Study:
- To evaluate glymphatic system function in neurologically asymptomatic early CKD patients compared to healthy controls.
- To utilize the diffusion tensor image analysis along perivascular space (DTI-ALPS) index for assessing glymphatic function.
Main Methods:
- A prospective study involving 18 early CKD patients and 18 healthy controls.
- Brain magnetic resonance imaging (MRI) with diffusion tensor imaging (DTI) was performed on all participants.
- The DTI-ALPS index was calculated using DSI software for DTI preprocessing and index estimation.
Main Results:
- Early CKD patients exhibited a significantly lower DTI-ALPS index compared to healthy controls (1.259 ± 0.199 vs. 1.477 ± 0.232, p = 0.004).
- No significant relationship was found between the DTI-ALPS index and other clinical factors in the correlation analysis.
Conclusions:
- The DTI-ALPS index indicates glymphatic system dysfunction in patients with early CKD.
- This dysfunction may play a role in the pathophysiology of neurological problems associated with early CKD, including cognitive impairment.
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