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Risk factors for severe COVID-19 in people with cystic fibrosis: A systematic review

Vito Terlizzi1, Marco Antonio Motisi2, Roberta Pellegrino2

  • 1Department of Paediatric Medicine, Cystic Fibrosis Centre, Anna Meyer Children's University Hospital, Florence, Italy.

Frontiers in Pediatrics
|August 25, 2022
PubMed

Insights

People with cystic fibrosis (CF) face higher COVID-19 risks, with factors like low FEV1 and diabetes increasing severity. Dornase alfa may offer protection, but more research is needed on specific therapies for CF patients.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Genetics

Background:

  • Individuals with cystic fibrosis (CF) are recognized as a vulnerable population at increased risk for severe COVID-19.
  • Variability in COVID-19 outcomes and hospitalization rates has been observed among CF patients.

Conclusions:

  • While most cystic fibrosis patients experience mild SARS-CoV-2 infections, specific subgroups are at higher risk for severe outcomes.
  • Current CF maintenance therapies generally lack a clear preventive effect against severe COVID-19, though dornase alfa may offer some protection.
  • Further research is essential to determine the impact of specific COVID-19 therapies and vaccination strategies in the cystic fibrosis population due to limited current data.
Abstract

Keywords:
CFTR modulatorsCOVID-19SARS-CoV-2cystic fibrosisrisk factors

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