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Updated: Aug 31, 2025

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Coronary artery bypass grafts to chronic occluded right coronary arteries
Maleen Fiddicke1, Felix Fleissner1, Tonita Brunkhorst1
1Department of Cardiothoracic-, Transplantation- and Vascular Surgery, Hannover Medical School, Hannover, Germany.
Insights
Revascularizing chronically occluded right coronary arteries during coronary artery bypass grafting significantly improves long-term survival. This study suggests routine RCA revascularization when feasible for better patient outcomes.
Area of Science:
- Cardiology
- Cardiovascular Surgery
- Interventional Cardiology
Background:
- The clinical benefit of revascularizing chronically occluded coronary arteries is debated.
- Long-term outcome data for these procedures are limited.
- Current guidelines suggest revascularization only for patients with ischemia or angina symptoms.
Purpose of the Study:
- To investigate the long-term outcomes of patients with total chronic occlusion of the right coronary artery (RCA) who underwent coronary artery bypass grafting (CABG).
- To compare outcomes between patients who received RCA revascularization (RCA-CABG) and those who did not (No-RCA-CABG).
Main Methods:
- Retrospective analysis of 587 patients with chronically occluded RCAs undergoing CABG.
- Patients were divided into two groups: RCA-CABG (n=487) and No-RCA-CABG (n=100).
- Minimum follow-up of 6 years was completed by 92% of patients.
Main Results:
- Both groups had comparable baseline characteristics and in-hospital mortality.
- Patients receiving RCA-CABG had more distal anastomoses (3.24 vs 2.45).
- Long-term survival was significantly better in the RCA-CABG group (P=.002).
Conclusions:
- Patients with chronically occluded RCAs undergoing CABG without RCA revascularization had significantly reduced long-term survival.
- Revascularization of chronically occluded right coronary arteries during CABG should be recommended when technically feasible.
Background:
The benefit of revascularizing chronically occluded coronary arteries remains debatable, and available long-term outcome reports are sparse. Current guidelines recommend revascularization of chronically occluded arteries only in patients with myocardial ischemia and/or symptoms associated with angina. We investigated outcome of patients with total chronic occlusion of the right coronary artery (RCA) receiving coronary artery bypass grafting (CABG) surgery with and without revascularization of the RCA.
Methods:
We retrospectively analyzed all patients with chronically occluded RCAs receiving CABG with (group 1 = RCA-CABG; n = 487) and without (group 2 = No-RCA-CABG; n = 100) revascularization of the RCA. In total, 587 patients with complete follow-up of a minimum of 6 years were included (92%).
Results:
In total, 82% in group 1 versus 86% in group 2 were male (P = .38). European System for Cardiac Operative Risk Evaluation II was comparable between both groups (4.35 ± 7.09% vs 4.80 ± 5.77%, P = .56) with no major differences regarding preoperative characteristics between groups. Patients in group 1 received 3.24 ± 0.79 distal anastomoses, whereas group 2 received 2.45 ± 0.83 distal anastomoses (P < .001). Although in-hospital mortality was comparable (2.9% in group 1 vs 5.0% in group 2, P = .27), long-term survival was significantly better in group 1 (P = .002). No difference in the incidence of further major adverse cardiac and cerebrovascular events was found.
Conclusions:
Patients with a chronically occluded RCA undergoing CABG who did not receive an RCA graft showed a significantly reduced long-term survival. Given the herein presented data, revascularization of chronically occluded right arteries during CABG should be recommended whenever technically feasible.
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