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Related Experiment Video

Updated: Aug 31, 2025

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Primary pulmonary synovial sarcoma.

Weixi Wang1, Junhong Guo2, Minwei Bao3

  • 1Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, China.

JTCVS Open
|August 25, 2022
PubMed
Summary

Primary pulmonary synovial sarcoma (PPSS) is aggressive. Postoperative chemotherapy and single lobe involvement improved survival, while pneumonectomy and lymph node involvement worsened it.

Keywords:
AJCC, American Joint Committee on CancerDSS, disease-specific survivalLN, lymph nodeOS, overall survivalPPSS, primary pulmonary synovial sarcomaSEER databaseSEER, Surveillance, Epidemiology, and End ResultsSS, synovial sarcomaSTS, soft tissue sarcomaoutcomesprimary pulmonary synovial sarcomasingle center study

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Area of Science:

  • Oncology
  • Thoracic Surgery
  • Pathology

Background:

  • Primary pulmonary synovial sarcoma (PPSS) is an exceptionally rare and aggressive malignancy.
  • Understanding clinicopathologic and therapeutic factors is crucial for improving patient outcomes.

Purpose of the Study:

  • To identify clinicopathologic and therapeutic factors influencing survival in patients with primary pulmonary synovial sarcoma.
  • To analyze survival data from a large database and an institutional cohort.

Main Methods:

  • Retrospective analysis of 121 patients from the Surveillance, Epidemiology, and End Results (SEER) Database.
  • Inclusion of 12 patients diagnosed at the authors' institution.
  • Kaplan-Meier method used for survival evaluation.

Main Results:

  • Median survival was 78 months in the institutional cohort and 23 months in the SEER cohort.
  • Postoperative chemotherapy and single lobe involvement were associated with improved survival.
  • Pneumonectomy and lymph node involvement correlated with worse survival.
  • Earlier American Joint Committee on Cancer (AJCC) stage (I-II) significantly predicted better survival.

Conclusions:

  • Primary pulmonary synovial sarcoma (PPSS) presents an aggressive clinical course with a poor prognosis.
  • AJCC staging, pneumonectomy, lymph node status, lobe involvement, and postoperative chemotherapy are key factors for survival prediction and management.