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The Role of TAMs in Tumor Microenvironment and New Research Progress

Yawei Feng1, Zhiqiang Ye2, Furong Song1

  • 1Department of Anesthesiology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Stem Cells International
|August 25, 2022
PubMed

Insights

Tumor-associated macrophages (TAMs) create a supportive tumor microenvironment (TME), promoting cancer growth and metastasis. Targeting TAMs offers a promising new strategy for cancer therapy.

Area of Science:

  • Immunology
  • Oncology
  • Cell Biology

Background:

  • Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment (TME).
  • TAMs play critical roles in tumor occurrence, growth, invasion, and metastasis.
  • Metastasis is a crucial step in malignant tumor development.

Purpose of the Study:

  • To summarize the latest advancements regarding TAMs' role in TME formation.
  • To explore the potential of TAM-targeted therapy for cancer treatment.

Main Methods:

  • Review of recent scientific literature.
  • Analysis of cell and animal experimental data.
  • Examination of clinical pathological findings.

Main Results:

  • Cell and animal studies indicate TAMs foster a pro-tumorigenic microenvironment.
  • Clinical data correlate TAM accumulation with poor treatment outcomes.
  • TAMs are implicated in promoting tumor growth and metastasis.

Conclusions:

  • TAMs significantly influence tumor progression and metastasis.
  • Targeting TAMs presents a viable therapeutic strategy for cancer.
  • This research provides a foundation for developing macrophage-targeted cancer therapies.

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