Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

Papillary Dermis

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen...

Flexural Stress

Flexural Stress

When analyzing bending in symmetric members, it's crucial to understand how stresses distribute when subjected to bending moments. This stress distribution is effectively described by applying fundamental mechanics and material science principles, particularly Hooke's Law for elastic materials.
Hooke's Law states that within the material's elastic limits, stress is directly proportional to strain. In a member experiencing a bending moment, the strain at any point is relative to...

Skin Diseases and Disorders

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

Burn Injuries

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same journal

Comment on 'Real-World Outcomes of Stapokibart-Based Combination Therapy for Bullous Pemphigoid: A Single-Center Retrospective Cohort': towards controlled comparisons, neurological profiling, and long-term follow-up.

Clinical and experimental dermatology·2026

Same journal

Comment on 'Long-term effectiveness of bimekizumab in plaque psoriasis: 2-year drug survival from a real-life multicenter Italian study'.

Clinical and experimental dermatology·2026

Same journal

Comment on 'Chromoblastomycosis in northern Taiwan from 2017 to 2024: unique characteristics'.

Clinical and experimental dermatology·2026

Same journal

Comment on 'The reliability and smallest detectable difference of the Severity of Alopecia Tool score in alopecia areata'.

Clinical and experimental dermatology·2026

Same journal

Comment on 'An open-label phase II study of bitopertin in adults and adolescents with erythropoietic protoporphyria or X-linked protoporphyria'.

Clinical and experimental dermatology·2026

Same journal

A peculiar xanthomatous eruption.

Clinical and experimental dermatology·2026

Search research articles

Related Experiment Video

Updated: Aug 31, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Erythematous flexural eruption in a young man.

¹Department of Dermatology, E-Da Cancer Hospital, Kaohsiung, Taiwan.

Clinical and Experimental Dermatology

|August 25, 2022

Summary

A young man with persistent skin plaques unresponsive to standard treatments was diagnosed with a rare condition. Histopathology revealed specific changes in the stratum corneum, indicating a need for targeted dermatological investigation.

Area of Science:

Dermatology
Histopathology

Background:

A young male presented with a two-week history of erythematous plaques in intertriginous areas.
Previous treatments including topical corticosteroids, antifungals, and oral prednisolone were ineffective.

Purpose of the Study:

To present a case study of a patient with treatment-resistant dermatological condition.
To highlight the diagnostic value of histopathological findings in complex skin cases.

Main Methods:

Clinical presentation of a young man with symmetrical erythematous plaques.
Histopathological examination of skin biopsy specimens.

Main Results:

Histopathology showed confluent parakeratosis.
Retention of basophilic keratohyalin granules within the stratum corneum was observed.

More Related Videos

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Related Experiment Videos

Last Updated: Aug 31, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Precision Implementation of Minimal Erythema Dose MED Testing to Assess Individual Variation in Human Inflammatory Response

Published on: October 3, 2019

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

Conclusions:

The histopathological findings suggest a specific diagnosis that requires further investigation.
This case underscores the importance of detailed histopathological analysis for challenging dermatological presentations.