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Chiral gold(III) complexes: speciation, in vitro, and in vivo anticancer profile
Adedamola S Arojojoye1, Jong H Kim1, Chibuzor Olelewe1
1Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA. awuah@uky.edu.
Chemical Communications (Cambridge, England)
|August 25, 2022
Abstract:
Emerging synthetic development of chiral gold(III) complexes has prompted new opportunities in catalysis and material science with limited utility in biomedicine. Here, we demonstrate potential chemotherapeutic capability of [C^N]Au(III)Cl(R-DuPhos) (1-7) complexes, containing 1,2-bis[(2R,5R)-2,5-dialkylphospholano]benzene, which shows good stabilty, potent anticancer activity, and tolerability in mice.
