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Blood Pressure Mediated the Effects of Urinary Uromodulin Levels on Myocardial Infarction: a Mendelian Randomization

Zhongyu Jian1,2, Chi Yuan1, Yucheng Ma1

  • 1Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, People's Republic of China (Z.J., C.Y., Y.M.).

Hypertension (Dallas, Tex. : 1979)
|August 25, 2022
PubMed

Insights

Higher urinary uromodulin (uUMOD) increases blood pressure, which in turn elevates myocardial infarction (MI) risk. This study clarifies a key pathway linking uUMOD to cardiovascular disease (CVD).

Area of Science:

  • Nephrology
  • Cardiology
  • Genetics

Background:

  • The relationship between urinary uromodulin (uUMOD) and cardiovascular disease (CVD) remains unclear.
  • Investigating causal links is crucial for understanding CVD pathogenesis.

Purpose of the Study:

  • To determine the causal effect of uUMOD on CVD.
  • To explore the mediating role of blood pressure in the uUMOD-CVD relationship.

Main Methods:

  • Bidirectional 2-sample Mendelian randomization was used to assess the uUMOD-CVD association.
  • Multivariable Mendelian randomization and mediation analysis investigated blood pressure's role.

Main Results:

  • Increased uUMOD levels causally linked to higher myocardial infarction (MI) risk (OR 1.08).
  • Blood pressure mediated the effect of uUMOD on MI, with significant indirect effects observed.
  • No causal link found between uUMOD and other CVD outcomes like stroke or heart failure.

Conclusions:

  • Higher uUMOD levels increase blood pressure, consequently raising MI risk.
  • Blood pressure is a key mediator in the uUMOD-associated MI pathway.
  • Further research is needed for other CVD outcomes.
Abstract

Keywords:
blood pressurecardiovascular diseasesmyocardial infarctionuromodulin

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